Free shipping on all orders over $ 500

BC-1215

Cat. No. M57279

All AbMole products are for research use only, cannot be used for human consumption.

BC-1215 Structure
Synonym:

BC1215

Size Price Availability Quantity
1mg USD 40  USD40 In stock
5mg USD 60  USD60 In stock
10mg USD 90  USD90 In stock
25mg USD 155  USD155 In stock
50mg USD 220  USD220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

BC-1215 is a novel inhibitor of F-box protein 3 (Fbxo3) activity. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 relieves allodynia by preventing ubiquitination-dependent Fbxl2/TRAF2/TNIK/pGluR1 signaling. BC-1215 exerted robust therapeutic effects in cytokine-driven inflammation, including pseudomona-induced lung injury and cecum ligation/punctured-induced sepsis, by targeting Fbxo3/Fbxl2/TRAF-mediated cytokine release. BC-1215 can be used for the research of inflammation.

Chemical Information
Molecular Weight 394.51
Formula C26H26N4
CAS Number 1507370-20-8
Solubility (25°C) DMSO 1 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related Ligand for E3 Ligase Products
OICR-8268

OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs.

VH 101, acid 

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development.

(S,R,S)-AHPC-Boc

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Lenalidomide-Br 

Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.

CRBN modulator-1 

CRBN modulator-1, a Thalidomide analog and a CRBN modulator, has an IC50 of 3.5 μM and a Ki of 0.98 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: BC-1215, BC1215 supplier, Ligand for E3 Ligase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.