Free shipping on all orders over $ 500

E3 ligase Ligand 4

Cat. No. M9834
E3 ligase Ligand 4 Structure

Thalidomide 4-fluoride

Size Price Availability Quantity
10mg USD 49  USD49 In stock
50mg USD 79  USD79 In stock
100mg USD 108  USD108 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

Chemical Information
Molecular Weight 276.22
Formula C13H9FN2O4
CAS Number 835616-60-9
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6

[2] Tasuku Ishida, et al. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

[3] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives

[4] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

[5] Jinfang Zhang, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

Related Ligand for E3 Ligase Products


2,6-Bis(benzyloxy)pyridine-3-boronic acid

2,6-Bis(benzyloxy)pyridine-3-boronic acid







Abmole Inhibitor Catalog

Keywords: E3 ligase Ligand 4, Thalidomide 4-fluoride supplier, Ligand for E3 Ligase, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.