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E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
Molecular Weight | 276.22 |
Formula | C13H9FN2O4 |
CAS Number | 835616-60-9 |
Solubility (25°C) | DMSO ≥ 100 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6
[3] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives
[4] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis
Related Ligand for E3 Ligase Products |
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2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
2,6-Bis(benzyloxy)pyridine-3-boronic acid
2,6-Bis(benzyloxy)pyridine-3-boronic acid |
2,6-Bis(benzyloxy)-3-bromopyridine
2,6-Bis(benzyloxy)-3-bromopyridine |
2,6-bis(benzyloxy)pyridin-3-amine
2,6-bis(benzyloxy)pyridin-3-amine |
3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione
3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione |
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