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E3 ligase Ligand 4

Cat. No. M9834

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E3 ligase Ligand 4 Structure
Synonym:

Thalidomide 4-fluoride

Size Price Availability Quantity
10mg USD 49  USD49 In stock
50mg USD 79  USD79 In stock
100mg USD 108  USD108 In stock
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Quality Control & Documentation
Biological Activity

E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

Chemical Information
Molecular Weight 276.22
Formula C13H9FN2O4
CAS Number 835616-60-9
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6

[2] Tasuku Ishida, et al. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

[3] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives

[4] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

[5] Jinfang Zhang, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

Related Ligand for E3 Ligase Products
OICR-8268

OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs.

BC-1215

BC-1215 is a novel inhibitor of F-box protein 3 (Fbxo3) activity. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 relieves allodynia by preventing ubiquitination-dependent Fbxl2/TRAF2/TNIK/pGluR1 signaling. BC-1215 exerted robust therapeutic effects in cytokine-driven inflammation, including pseudomona-induced lung injury and cecum ligation/punctured-induced sepsis, by targeting Fbxo3/Fbxl2/TRAF-mediated cytokine release. BC-1215 can be used for the research of inflammation.

VH 101, acid 

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development.

(S,R,S)-AHPC-Boc

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Lenalidomide-Br 

Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.

  Catalog
Abmole Inhibitor Catalog




Keywords: E3 ligase Ligand 4, Thalidomide 4-fluoride supplier, Ligand for E3 Ligase, inhibitors, activators

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