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E3 ligase Ligand 1 (VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
| Molecular Weight | 481.05 |
| Formula | C23H33ClN4O3S |
| CAS Number | 1948273-03-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ligand for E3 Ligase Products |
|---|
| 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
| 2,6-Bis(benzyloxy)pyridine-3-boronic acid
2,6-Bis(benzyloxy)pyridine-3-boronic acid |
| 2,6-Bis(benzyloxy)-3-bromopyridine
2,6-Bis(benzyloxy)-3-bromopyridine |
| 2,6-bis(benzyloxy)pyridin-3-amine
2,6-bis(benzyloxy)pyridin-3-amine |
| 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione
3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione |
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