E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
Molecular Weight | 530.61 |
CAS Number | 1225383-33-4 |
Solubility (25°C) | DMSO 90 mg/mL |
Storage | 2-8°C, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Yasmina Filali-Mouncef, et al. The ménage à trois of autophagy, lipid droplets and liver disease
[2] Yifan Chen, et al. Phosphorylation regulates cullin-based ubiquitination in tumorigenesis
[3] Dhanusha A Nalawansha, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine
[4] Ye Xu, et al. Emerging views of mitophagy in immunity and autoimmune diseases
[5] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis
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CC-90009
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VH032
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