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PT-179

Cat. No. M55581

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PT-179 Structure
Synonym:

PT179

Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 200  USD200 In stock
25mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

PT-179 is an orthogonal Thalidomide (M2225) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. PT-179 (1-10 μM; 24 h) can induce eGFP degradation in HEK293T cells. The higher the evolution degree of the degron variant, the stronger the degradation efficiency of the corresponding tagged protein. SD40 is a degradation tag specific for PT-179. PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms.

Chemical Information
Molecular Weight 343.33
Formula C17H17N3O5
CAS Number 2924858-25-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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  Catalog
Abmole Inhibitor Catalog




Keywords: PT-179, PT179 supplier, Ligand for E3 Ligase, inhibitors, activators

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