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Ligand for E3 Ligase Ligand for E3 Ligase

Cat.No.  Name Information
M2225 Thalidomide Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.
M57119 (S,R,S)-AHPC-Boc (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M57118 Lenalidomide-Br  Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
M57117 CRBN modulator-1  CRBN modulator-1, a Thalidomide analog and a CRBN modulator, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
M57116 Lenalidomide-4-OH  Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.
M57115 (S,R,S)-AHPC TFA (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M57114 Nutlin carboxylic acid Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand.
M57113 cIAP1 ligand 1 cIAP1 ligand 1 is the LCL161 derivative based IAP ligand.
M57112 Pomalidomide-piperazine  Pomalidomide-piperazine is an active compound that can be used to synthesis the E3 ligand for PROTAC.
M57111 (S,R,S)-AHPC dihydrochloride (S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M43915 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
M43914 2,6-Bis(benzyloxy)pyridine-3-boronic acid 2,6-Bis(benzyloxy)pyridine-3-boronic acid
M43912 2,6-bis(benzyloxy)pyridin-3-amine 2,6-bis(benzyloxy)pyridin-3-amine
M43910 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione
M43905 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]- 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]-
M43904 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)- 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)-
M43903 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]- 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]-
M43902 2,6-Piperidinedione, 3-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]- 2,6-Piperidinedione, 3-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]-
M43899 2,6-Piperidinedione, 3-[[3-fluoro-4-(4-piperidinyl)phenyl]amino]- 2,6-Piperidinedione, 3-[[3-fluoro-4-(4-piperidinyl)phenyl]amino]-
M43898 3-((4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione 3-((4-(piperidin-4-yl)phenyl)amino)piperidine-2,6-dione
M43895 tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidine-1-carboxylate tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidine-1-carboxylate




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