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CC-885

Cat. No. M14863

All AbMole products are for research use only, cannot be used for human consumption.

CC-885 Structure
Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 170  USD170 In stock
25mg USD 385  USD385 In stock
50mg USD 570  USD570 In stock
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Quality Control & Documentation
Biological Activity

CC-885 is a regulator of CRBN protein with a wide range of strong CRBN-dependent anti-proliferative activity in various tumor cell lines, with enhanced anti-proliferative activity compared to lenalidomide and pomalidomide.CC-885 promotes the binding of CRBN to the novel substrate GSPT1, targeting its degradation.

Chemical Information
Molecular Weight 440.88
CAS Number 1010100-07-8
Solubility (25°C) DMSO 67.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alireza Baradaran-Heravi, et al. Effect of small molecule eRF3 degraders on premature termination codon readthrough

[2] Min Zhao, et al. Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma

[3] Lifeng Li, et al. A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer

[4] Bing-Bing Hao, et al. The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

[5] Mary E Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

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  Catalog
Abmole Inhibitor Catalog




Keywords: CC-885 supplier, Ligand for E3 Ligase, inhibitors, activators

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