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Nitazoxanide

Cat. No. M3433

All AbMole products are for research use only, cannot be used for human consumption.

Nitazoxanide Structure
Synonym:

NTZ; NSC 697855

Size Price Availability Quantity
1mg USD 15  USD15 In stock
5mg USD 30  USD30 In stock
10mg USD 50  USD50 In stock
50mg USD 130  USD130 In stock
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Nitazoxanide (Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate: ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively.

Chemical Information
Molecular Weight 307.28
Formula C12H9N3O5S
CAS Number 55981-09-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Patricia R M Rocco, et al. Early use of nitazoxanide in mild COVID-19 disease: randomised, placebo-controlled trial

[2] Amit S Lokhande, et al. A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19

[3] Jos Meneses Caldern, et al. Nitazoxanide against COVID-19 in three explorative scenarios

[4] No authors listed. Nitazoxanide

[5] Jean-Franois Rossignol. Nitazoxanide: a first-in-class broad-spectrum antiviral agent

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Keywords: Nitazoxanide, NTZ; NSC 697855 supplier, Anti-infection, inhibitors, activators

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