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Cat. No. M3433
Nitazoxanide Structure

NTZ; NSC 697855

Size Price Availability Quantity
10mg USD 55  USD55 In stock
50mg USD 180  USD180 In stock
100mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Nitazoxanide (Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate: ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively.

Chemical Information
Molecular Weight 307.28
Formula C12H9N3O5S
CAS Number 55981-09-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Patricia R M Rocco, et al. Early use of nitazoxanide in mild COVID-19 disease: randomised, placebo-controlled trial

[2] Amit S Lokhande, et al. A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19

[3] Jos Meneses Caldern, et al. Nitazoxanide against COVID-19 in three explorative scenarios

[4] No authors listed. Nitazoxanide

[5] Jean-Franois Rossignol. Nitazoxanide: a first-in-class broad-spectrum antiviral agent

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Keywords: Nitazoxanide, NTZ; NSC 697855 supplier, Anti-infection, inhibitors, activators

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