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Oseltamivir

Cat. No. M1959

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Oseltamivir Structure
Synonym:

Tamiflu

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 30  USD30 In stock
10mg USD 50  USD50 In stock
50mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Oseltamivir (trade name Tamiflu) is an ethyl ester prodrug of Ro 64-0802, a neuraminidase inhibitor, serving as a competitive inhibitor of the activity of the viral neuraminidase (NA) enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells. Oral administration of oseltamivir delivers the active antiviral Ro 64-0802 to the bloodstream, and thus all sites of influenza infection (lung, nasal mucosa, middle ear) are accessible. Oseltamivir (Tamiflu) was the first orally active neuraminidase inhibitor commercially developed. Treatment with oseltamivir does not seem to adversely affect the primary in vivo cellular immune responses to influenza virus infection.

Product Citations
Chemical Information
Molecular Weight 312.4
Formula C16H28N2O4
CAS Number 196618-13-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jiangnan Zhao, et al. Sci Rep. Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus

[2] Collins PJ, et al. Nature. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.

[3] He G, et al. Clin Pharmacokinet. Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.

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Keywords: Oseltamivir, Tamiflu supplier, Anti-infection, inhibitors, activators

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