Free shipping on all orders over $ 500


Cat. No. M1959
Oseltamivir Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 30  USD30 In stock
10mg USD 50  USD50 In stock
50mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Oseltamivir (trade name Tamiflu) is an ethyl ester prodrug of Ro 64-0802, a neuraminidase inhibitor, serving as a competitive inhibitor of the activity of the viral neuraminidase (NA) enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells. Oral administration of oseltamivir delivers the active antiviral Ro 64-0802 to the bloodstream, and thus all sites of influenza infection (lung, nasal mucosa, middle ear) are accessible. Oseltamivir (Tamiflu) was the first orally active neuraminidase inhibitor commercially developed. Treatment with oseltamivir does not seem to adversely affect the primary in vivo cellular immune responses to influenza virus infection.

Product Citations
Chemical Information
Molecular Weight 312.4
Formula C16H28N2O4
CAS Number 196618-13-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jiangnan Zhao, et al. Sci Rep. Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus

[2] Collins PJ, et al. Nature. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.

[3] He G, et al. Clin Pharmacokinet. Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.

Related Anti-infection Products

Fomivirsen is a phosphorothioate oligonucleotide derivative that binds to and degrades the mRNA of the CMV immediate-early 2 protein, thereby inhibiting viral proliferation, and can be used in studies related to cytomegalovirus retinitis (CMV).


Bucillamine is an orally active endogenous cysteine derivative of the amino acid that also acts as a sulfhydryl donor with antiangiogenic, antioxidant, and anti-inflammatory activities, and is used in rheumatoid arthritis (RA), cystinuria, and gout studies.

β-Amyrin acetate

β-Amyrin acetate is a triterpenoid natural product that localizes to HMG CoA reductase and inhibits its activity, with potent anti-inflammatory, anti-fungal, anti-diabetic, and anti-hyperlipidemic activities.

Rabbit defensin NP-1

Rabbit defensin NP-1, a defensin isolated from rabbit neutrophils, consists of 33 amino acids rich in arginine and cysteine residues and has antimicrobial activity.

Human β-defensin-3

Human β-defensin-3 is an antimicrobial peptide produced by epithelial cells that reduces inflammatory cytokine responses, as well as inhibits microbial growth, and has immunomodulatory activity with IC90 values ranging from 6-25 μg/ml.

Abmole Inhibitor Catalog

Keywords: Oseltamivir, Tamiflu supplier, Anti-infection, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.