Oseltamivir (trade name Tamiflu) is an ethyl ester prodrug of Ro 64-0802, a neuraminidase inhibitor, serving as a competitive inhibitor of the activity of the viral neuraminidase (NA) enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells. Oral administration of oseltamivir delivers the active antiviral Ro 64-0802 to the bloodstream, and thus all sites of influenza infection (lung, nasal mucosa, middle ear) are accessible. Oseltamivir (Tamiflu) was the first orally active neuraminidase inhibitor commercially developed. Treatment with oseltamivir does not seem to adversely affect the primary in vivo cellular immune responses to influenza virus infection.
Food Funct. 2016 Mar 24.
Neuraminidase inhibition of Dietary chlorogenic acids and derivatives - potential antivirals from dietary sources.
Oseltamivir purchased from AbMole
|Solubility (25°C)||DMSO ≥ 30 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Anti-infection Products|
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β-Amyrin acetate is a triterpenoid natural product that localizes to HMG CoA reductase and inhibits its activity, with potent anti-inflammatory, anti-fungal, anti-diabetic, and anti-hyperlipidemic activities.
|Rabbit defensin NP-1
Rabbit defensin NP-1, a defensin isolated from rabbit neutrophils, consists of 33 amino acids rich in arginine and cysteine residues and has antimicrobial activity.
Human β-defensin-3 is an antimicrobial peptide produced by epithelial cells that reduces inflammatory cytokine responses, as well as inhibits microbial growth, and has immunomodulatory activity with IC90 values ranging from 6-25 μg/ml.
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