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Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research.
J Virol. 2025 Feb 05.
The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication
Denifanstat purchased from AbMole
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| Animal models | female C57/BL6 mice |
| Formulation | formulated in 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline |
| Dosages | 25 mg/kg |
| Administration | daily gavage |
| Molecular Weight | 439.55 |
| Formula | C27H29N5O |
| CAS Number | 1399177-37-7 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
| Related FAS Products |
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| FASN-IN-4 tosylate
FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM. FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM. |
| Fasnall
Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. |
| Fasnall benzenesulfonate
Fasnall benzenesulfonate is the benzenesulfonate salt form of Fasnall. |
| GSK837149A
GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer. |
| IPI-9119
IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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