Free shipping on all orders over $ 500

GSK837149A 

Cat. No. M28252

All AbMole products are for research use only, cannot be used for human consumption.

GSK837149A  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer.

Chemical Information
Molecular Weight 554.6
Formula C23H22N8O5S2
CAS Number 13616-29-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Prosanta K Singha, et al. Eur J Pharm Sci. Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells

[2] María Jesús Vázquez, et al. FEBS J. Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction

Related FAS Products
Fasnall 

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM.
Fasnall benzenesulfonate 

Fasnall benzenesulfonate is the benzenesulfonate salt form of Fasnall.
IPI-9119

IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM.
Eicosapentaenoic acid ethyl ester

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
FT113

FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM.
  Catalog
Abmole Inhibitor Catalog




Keywords: GSK837149A  supplier, FAS, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.