|IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM.
|PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM.
|Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant.
|Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
|Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research.
|TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
|GLPG0974 is a potent and selective free fatty acid receptor-2 (FFA2/GPR43) antagonist, with an IC50 of 9 nM.
|Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.
|Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended
|Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
|C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.
|FGH10019 is a novel SREBP (sterol regulatory element-binding protein) inhibitor, with IC50 of 1 μM.
|TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.
|Cyanogen is an antibiotic and antifungal compound, which is an inhibitor of fatty acid biosynthesis. < I > In vitro inhibition of HIV-1 protease.
|Pedunculoside plays a lipid-lowering role by regulating lipid formation and fatty acid β -oxidation.
|Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity.
|Pseudoprotodioscin, a furan glucoside, inhibits sREBP1/2 and microRNA 33A/B levels and reduces the expression of genes associated with cholesterol and triglyceride synthesis.
|Betulin is a specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins).
|Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice.
|C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS).
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