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FAS Fatty Acid Synthase

Inhibitors

Cat.No.  Name Information
M20994 Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
M20690 FT113 FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM.
M14435 PF429242 dihydrochloride PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM.
M14434 Lycorine Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant.
M14433 FASN-IN-1 FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56.
M14432 FASN-IN-4 tosylate FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.
M14431 Desoxyrhaponticin Desoxyrhaponticin is a stilbene glycoside from the Tibetan nutritional food Rheum tanguticum Maxim. Desoxyrhaponticin is a Fatty acid synthase (FASN) inhibitor, and has apoptotic effect on human cancer cells.
M14430 BI 99179 BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM.
M13962 Fasiglifam Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
M13961 GW-1100 GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
M10175 TVB-3664 TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
M10096 GLPG0974 GLPG0974 is a potent and selective free fatty acid receptor-2 (FFA2/GPR43) antagonist, with an IC50 of 9 nM.
M10068 Triheptanoin Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.
M10066 AP1903 (Rimiducid) Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended
M10052 Fatostatin Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
M9508 C75 trans C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.
M3549 Orlistat Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice.
M2604 C75 C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS).



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