| Cat.No. | Name | Information |
|---|---|---|
| M25471 | IPI-9119 | IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM. |
| M14435 | PF429242 dihydrochloride | PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM. |
| M14434 | Lycorine | Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. |
| M13962 | Fasiglifam | Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM. |
| M10746 | Denifanstat | Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research. |
| M10175 | TVB-3664 | TVB-3664 is a FASN inhibitor with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression. |
| M10096 | GLPG0974 | GLPG0974 is a potent and selective free fatty acid receptor-2 (FFA2/GPR43) antagonist, with an IC50 of 9 nM. |
| M10068 | Triheptanoin | Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator. |
| M10066 | AP1903 (Rimiducid) | Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended |
| M10052 | Fatostatin | Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division. |
| M9508 | C75 trans | C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor. |
| M9495 | FGH10019 | FGH10019 is a novel SREBP (sterol regulatory element-binding protein) inhibitor, with IC50 of 1 μM. |
| M8622 | TVB-3166 | TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. |
| M7704 | Cerulenin | Cyanogen is an antibiotic and antifungal compound, which is an inhibitor of fatty acid biosynthesis. In vitro inhibition of HIV-1 protease. |
| M4728 | Pedunculoside | Pedunculoside plays a lipid-lowering role by regulating lipid formation and fatty acid β -oxidation. |
| M4643 | Albaspidin-AP | Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity. |
| M4366 | Pseudoprotodioscin | Pseudoprotodioscin, a furan glucoside, inhibits sREBP1/2 and microRNA 33A/B levels and reduces the expression of genes associated with cholesterol and triglyceride synthesis. |
| M3996 | Betulin | Betulin is a specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins). |
| M3549 | Orlistat | Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice. |
| M2604 | C75 | C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). C75 inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. |
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