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FAS Fatty Acid Synthase

Cat.No.  Name Information
M25471 IPI-9119 IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM.
M14435 PF429242 dihydrochloride PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM.
M14434 Lycorine Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant.
M13962 Fasiglifam Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
M10746 Denifanstat Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research.
M10175 TVB-3664 TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
M10096 GLPG0974 GLPG0974 is a potent and selective free fatty acid receptor-2 (FFA2/GPR43) antagonist, with an IC50 of 9 nM.
M10068 Triheptanoin Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.
M10066 AP1903 (Rimiducid) Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended
M10052 Fatostatin Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
M9508 C75 trans C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.
M9495 FGH10019 FGH10019 is a novel SREBP (sterol regulatory element-binding protein) inhibitor, with IC50 of 1 μM.
M8622 TVB-3166 TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.
M7704 Cerulenin Cyanogen is an antibiotic and antifungal compound, which is an inhibitor of fatty acid biosynthesis. < I > In vitro inhibition of HIV-1 protease.
M4728 Pedunculoside Pedunculoside plays a lipid-lowering role by regulating lipid formation and fatty acid β -oxidation.
M4643 Albaspidin-AP Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity.
M4366 Pseudoprotodioscin Pseudoprotodioscin, a furan glucoside, inhibits sREBP1/2 and microRNA 33A/B levels and reduces the expression of genes associated with cholesterol and triglyceride synthesis.
M3996 Betulin Betulin is a specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins).
M3549 Orlistat Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice.
M2604 C75 C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS).




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