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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M20994 | Eicosapentaenoic acid ethyl ester | Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels. |
| M20690 | FT113 | FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM. |
| M14435 | PF429242 dihydrochloride | PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM. |
| M14434 | Lycorine | Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. |
| M14433 | FASN-IN-1 | FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56. |
| M14432 | FASN-IN-4 tosylate | FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM. |
| M14431 | Desoxyrhaponticin | Desoxyrhaponticin is a stilbene glycoside from the Tibetan nutritional food Rheum tanguticum Maxim. Desoxyrhaponticin is a Fatty acid synthase (FASN) inhibitor, and has apoptotic effect on human cancer cells. |
| M14430 | BI 99179 | BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. |
| M13962 | Fasiglifam | Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM. |
| M13961 | GW-1100 | GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. |
| M10175 | TVB-3664 | TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression. |
| M10096 | GLPG0974 | GLPG0974 is a potent and selective free fatty acid receptor-2 (FFA2/GPR43) antagonist, with an IC50 of 9 nM. |
| M10068 | Triheptanoin | Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator. |
| M10066 | AP1903 (Rimiducid) | Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended |
| M10052 | Fatostatin | Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division. |
| M9508 | C75 trans | C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor. |
| M3549 | Orlistat | Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice. |
| M2604 | C75 | C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). |
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