All AbMole products are for research use only, cannot be used for human consumption.
Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
| Cell Experiment | |
|---|---|
| Cell lines | CHO-K1 cells |
| Preparation method | CHO-K1 cells are plated out onto a 96-well plate in medium A. The cells are transiently cotransfected with pCMV-PLAP-BP2, pCMV-SCAP, and pAc-b-gal, using Lipofectamine reagent. After incubation for 5 hr, the cells are washed with PBS and then incubated in medium B, in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol). After 20 hr of incubation, an aliquot of the medium is assayed for secreted alkaline phosphatase activity. The cells in each well are lysed and used for measurement of b-galactosidase activities. |
| Concentrations | 20 μM |
| Incubation time | 20 h |
| Animal Experiment | |
|---|---|
| Animal models | Four-to-five-week-old homozygous male obese (ob/ob) mice |
| Formulation | 10% DMSO in PBS |
| Dosages | 30 mg/kg; 150 uL |
| Administration | i.p. injection |
| Molecular Weight | 294.41 |
| Formula | C18H18N2S |
| CAS Number | 125256-00-0 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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