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C75

Cat. No. M2604
C75 Structure
Size Price Availability
2mg USD 140 Out of stock
5mg USD 200 Out of stock
10mg USD 380 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer. C75 inhibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1) in primary cortical neurons, consistent with its effects in peripheral tissues. C75 alters neuronal ATP levels and AMP-activated protein kinase (AMPK) activity. C75 displays anorectic effects. C75 induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Several downstream pathways are affected by C75 treatment, including glucose metabolism and acetyl-CoA carboxylase (ACC) phosphorylation. C75 modulates the levels of energy intermediates, thus, affecting the energy sensor AMPK.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 254.32
Formula C14H22O4
CAS Number 218137-86-1
Purity >98%
Solubility DMSO 5 mg/mL
Storage at -20°C
References

C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.
Landree LE, et al. J Biol Chem. 2004 Jan 30;279(5):3817-27. PMID: 14615481.

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Zhou W, et al. Cancer Res. 2003 Nov 1;63(21):7330-7. PMID: 14612531.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: C75 supplier, FAS, inhibitors

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