C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer. C75 inhibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1) in primary cortical neurons, consistent with its effects in peripheral tissues. C75 alters neuronal ATP levels and AMP-activated protein kinase (AMPK) activity. C75 displays anorectic effects. C75 induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Several downstream pathways are affected by C75 treatment, including glucose metabolism and acetyl-CoA carboxylase (ACC) phosphorylation. C75 modulates the levels of energy intermediates, thus, affecting the energy sensor AMPK.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 5 mg/mL|
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism.
Landree LE, et al. J Biol Chem. 2004 Jan 30;279(5):3817-27. PMID: 14615481.
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Zhou W, et al. Cancer Res. 2003 Nov 1;63(21):7330-7. PMID: 14612531.
|Related FAS Products|
TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
GLPG0974 is a potent and selective FFA2 (also called GPR43) antagonist.
Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.
Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains.
Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.