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IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM. IPI-9119 (0.05-5 μM; 6 days) significantly decreased AR-FL protein levels in AD LNCaP, AI C4-2 cells (expressing only AR-FL) and reduced the expression of AR-V7 in LNCaP-95, 22Rv1 AI cells.
In vivo, IPI-9119 (SC pump infusion; 0.5 μL/h; 100 mg/mL; for 28 days) inhibits tumor growth of CRPC xenografts mouse models.
| Molecular Weight | 495.43 |
| Formula | C24H19F2N5O5 |
| CAS Number | 1346564-56-4 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Suzanne F Jones, et al. Clin Cancer Res. Molecular Pathways: Fatty Acid Synthase
| Related FAS Products |
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| GSK837149A
GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer. |
| Eicosapentaenoic acid ethyl ester
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| FT113
FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM. |
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