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AP1903 (Rimiducid)

Cat. No. M10066

All AbMole products are for research use only, cannot be used for human consumption.

AP1903 (Rimiducid) Structure
Synonym:

Rimiducid

Size Price Availability Quantity
1mg USD 135  USD135 In stock
2mg USD 195  USD195 In stock
5mg USD 350  USD350 In stock
10mg USD 510  USD510 In stock
25mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. In vivo, Rimiducid (0.01, 0.1, 1, 10, and 100 mg/kg; i.v.) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 1411.63
Formula C78H98N4O20
CAS Number 195514-63-7
Solubility (25°C) DMSO 48 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] D C Thomis, et al. Blood. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

[2] T Clackson, et al. Proc Natl Acad Sci U S A. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

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Keywords: AP1903 (Rimiducid), Rimiducid supplier, FAS, inhibitors, activators

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