Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. In vivo, Rimiducid (0.01, 0.1, 1, 10, and 100 mg/kg; i.v.) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 48 mg/mL|
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
D C Thomis, et al. Blood. 2001 Mar 1;97(5):1249-57. PMID: 11222367.
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
T Clackson, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42. PMID: 9724721.
|Related FAS Products|
TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
GLPG0974 is a potent and selective FFA2 (also called GPR43) antagonist.
Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator.
Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.