Free shipping on all orders over $ 500

PF429242 dihydrochloride

Cat. No. M14435
PF429242 dihydrochloride Structure
Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 220  USD220 In stock
25mg USD 470  USD470 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 482.49
Formula
CAS Number 2248666-66-0
Purity >99%
Solubility DMSO ≥ 83.3 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Thais Tenorio Soares Fujii, et al. Microorganisms. Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

Related FAS Products
Eicosapentaenoic acid ethyl ester

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.

FT113

FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM.

Lycorine

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant.

FASN-IN-1

FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56.

FASN-IN-4 tosylate

FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: PF429242 dihydrochloride supplier, FAS, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.