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Fasentin

Cat. No. M7805

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Fasentin Structure

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Quality Control & Documentation
Biological Activity

Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.

Chemical Information
Molecular Weight 279.64
Formula C11H9ClF3NO2
CAS Number 392721-37-8
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ayaka Ito, et al. Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal

[2] M Carmen Ocaa, et al. Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner

[3] Ali F Abdel-Wahab, et al. Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

[4] Maheedhara R Guda, et al. GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets

[5] Tabitha E Wood, et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

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Abmole Inhibitor Catalog




Keywords: Fasentin supplier, inhibitors, activators

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