Free shipping on all orders over $ 500

Fasudil hydrochloride

Cat. No. M1872
Fasudil hydrochloride Structure

HA-1077; AT877

Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 83  USD83 In stock
500mg USD 135  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Fasudil hydrochloride is a cyclic nucleotide-dependent Rho-associated kinase inhibitor with IC50 of 10.7 μM. The Rho-kinase (ROCK) plays an important role in mediating vasoconstriction and vascular remodeling in the pathogenesis of PH. ROCK increases ACE expression and activity in PH. By inhibiting ROCK with fasudil, circulating ACE and Ang-II are reduced, leading to a decrease in pulmonary vascular pressure, thus decreasing MLC phosphatase activity and enhancing vascular smooth muscle contraction. Fasudil effectively inhibited ISO-induced heart failure, as evaluated by biometric, hemodynamic, and histological examinations. More over, fasudil significantly decreased ISO-induced JNK activation, ERK translocation to the nucleus and subsequent c-fos, c-jun expression and upregulated c-FLIP(L) expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 327.83
Formula C14H17N3O2S.HCl
CAS Number 105628-07-7
Purity >99%
Solubility Water ≥60 mg/mL
Storage at -20°C

[1] Manish Kumar, et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB

[2] Yiqing Zhang, et al. Effects of fasudil on pulmonary hypertension in clinical practice

[3] Peng Zeng, et al. Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice

[4] Wei-Dong Xiao, et al. Fasudil hydrochloride could promote axonal growth through inhibiting the activity of ROCK

[5] Takanari Kitazono. Fasudil hydrochloride

Related ROCK Products

Rock2-in-2 is a selective ROCK2 inhibitor with IC50 <1 μM.


SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

Belumosudil mesylate

Belumosudil mesylate (SLx-2119 mesylate) is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively).


BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

Belumosudil (SLx-2119)

SLx-2119, also known as KD-025, is an orally bioavailable inhibitor of ROCK-II with IC50 of 105 nM.

Abmole Inhibitor Catalog 2017

Keywords: Fasudil hydrochloride, HA-1077; AT877 supplier, ROCK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.