ROCK Rho-associated protein kinase

Cat.No.	Name	Information
M7388	TC-S 7001	TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active.
M5168	GSK269962A	GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively.
M5123	Y-39983 dihydrochloride	Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632.
M4938	H-1152	H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
M1856	Thiazovivin	Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts.
M1817	Y-27632 dihydrochloride	Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis.
M40755	Netarsudil dimesylate	Netarsudil dimesylate is a Rho-kinase (ROCK) inhibitor with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow via the trabecular pathway, reducing IOP and may be used in glaucoma-related studies.
M40625	Zelasudil	Zelasudil (RXC-007) is a selective ROCK2 inhibitor for studies related to idiopathic pulmonary fibrosis.
M21675	Cotosudil	Cotosudil is a ROCK kinase inhibitor. Cotosudil can be used for glaucoma or ocular hypertension research.
M20999	Y-27632	Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
M20640	MBQ-167	MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.
M13733	Y-33075	Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
M13727	H-1152 dihydrochloride	H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
M13726	Chroman 1	Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM.
M9678	SAR407899	SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
M9619	Belumosudil mesylate	Belumosudil mesylate (SLx-2119 mesylate) is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively).
M9211	BDP5290	BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
M9209	Belumosudil (SLx-2119)	Belumosudil (SLx-2119), also known as KD-025, is an orally bioavailable inhibitor of ROCK-II with IC50 of 105 nM.
M9032	ZINC00881524	ZINC00881524 is a potent and selective ROCK inhibitor.
M7016	Narciclasine	Narciclasine is a antiproliferative agent; slows cell cycle progression. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

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ROCK Rho-associated protein kinase

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