| Cat.No. | Name | Information |
|---|---|---|
| M7388 | TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active. |
| M5168 | GSK269962A | GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively. |
| M4938 | H-1152 | H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| M1817 | Y-27632 dihydrochloride | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| M40755 | Netarsudil dimesylate | Netarsudil dimesylate is a Rho-kinase (ROCK) inhibitor with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow via the trabecular pathway, reducing IOP and may be used in glaucoma-related studies. |
| M40625 | Zelasudil | Zelasudil (RXC-007) is a selective ROCK2 inhibitor for studies related to idiopathic pulmonary fibrosis. |
| M21675 | Cotosudil | Cotosudil is a ROCK kinase inhibitor. Cotosudil can be used for glaucoma or ocular hypertension research. |
| M20999 | Y-27632 | Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| M20640 | MBQ-167 | MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells. |
| M13733 | Y-33075 | Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. |
| M13727 | H-1152 dihydrochloride | H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. |
| M13726 | Chroman 1 | Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM. |
| M9678 | SAR407899 | SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. |
| M9619 | Belumosudil mesylate | Belumosudil mesylate (SLx-2119 mesylate) is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). |
| M9211 | BDP5290 | BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. |
| M9209 | Belumosudil (SLx-2119) | Belumosudil (SLx-2119), also known as KD-025, is an orally bioavailable inhibitor of ROCK-II with IC50 of 105 nM. |
| M9032 | ZINC00881524 | ZINC00881524 is a potent and selective ROCK inhibitor. |
| M7016 | Narciclasine | Narciclasine is a antiproliferative agent; slows cell cycle progression. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner. |
| M5933 | Ripasudil (K-115) dihydrate | Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. |
| M5339 | SR 3677 | SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
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