| Cat.No. | Name | Information |
|---|---|---|
| M1817 | Y-27632 dihydrochloride | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| M5168 | GSK269962A | GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively. |
| M7388 | TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active. |
| M4938 | H-1152 | H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| M1856 | Thiazovivin | Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. |
| M5123 | Y-39983 dihydrochloride | Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632. |
| M40627 | BA-1076 | BA-1076 is a ROCK1/2 inhibitor that can be used in glaucoma-related studies. |
| M40626 | AR-13503 | AR-13503 is an active metabolite of Netarsudil and a PKC/ROCK inhibitor that inhibits angiogenesis and enhances retinal pigment epithelium (RPE) permeability. It can be used in studies related to diabetic macular edema and macular degeneration. |
| M40624 | OPL-0401 | OPL-0401 is an orally active small molecule Rho-kinase (ROCK 1/2) inhibitor for studies related to non-proliferative diabetic retinopathy. |
| M40623 | Fasudil mesylate | Fasudil mesylate is a potent inhibitor of ROCKs with neuroprotective activity for studies related to cerebral infarction. |
| M31008 | Sovesudil hydrochloride | Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia. |
| M30754 | PT-262 | PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity. |
| M30264 | WF-536 | WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer. |
| M29403 | Ripasudil free base | Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. |
| M28366 | Verosudil | Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork. |
| M28188 | Sovesudil | Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia. |
| M28062 | PF-4950834 | PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration. |
| M20607 | BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. |
| M20596 | K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C). |
| M20595 | K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
| M20594 | 6H05 | 6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). |
| M20378 | WAY-624704 | WAY-624704 is a ROCK inhibitor. |
| M20340 | WAY-301300 | WAY-301300 is a Rho kinase inhibitor. |
| M20311 | WAY-226683 | WAY-226683 is a Rho kinase inhibitor. |
| M20286 | WL-300778 | WL-300778 is a inhibitor of Rho associated protein kinases (ROCK1 and 2) |
| M20280 | WAY-658513 | WAY-658513 is a inhibitor of ROCK, ERK, GSK, and AGC protein kinases. |
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