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Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632.
Theranostics. 2024 Sep 9;14(15):5762-5777.
ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Y-39983 dihydrochloride purchased from AbMole
Theranostics. 2024 Sep 09;14(15):5762-5777.
ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Y-39983 dihydrochloride purchased from AbMole
| Molecular Weight | 353.25 |
| Formula | C16H18Cl2N4O |
| CAS Number | 173897-44-4 |
| Solubility (25°C) | DMSO 80 mg/mL Water 40 mg/mL |
| Storage | 4°C, dry, sealed |
| Related ROCK Products |
|---|
| OXA-06 hydrochloride
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. |
| Y-33075 hydrochloride
Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. |
| SR-3677 dihydrochloride
SR-3677 dihydrochloride is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM. |
| Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. |
| Scaff10-8
Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation. |
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Products are for research use only. Not for human use. We do not sell to patients.
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