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Y-39983 dihydrochloride

Cat. No. M5123
Y-39983 dihydrochloride Structure
Synonym:

Y-33075 dihydrochloride

Size Price Availability
2mg USD 90  USD100 Out of stock
5mg USD 121.5  USD135 Out of stock
10mg USD 198  USD220 Out of stock
50mg USD 792  USD880 Out of stock
100mg USD 1305  USD1450 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Y-39983 Hcl is a selective ROCK inhibitor derived from Y-27632, inhibited ROCK more potently than Y-27632.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 353.25
Formula C16H18Cl2N4O
CAS Number 173897-44-4
Purity >98%
Solubility 10 mM in DMSO
10 mM in Water
Storage at -20°C
References


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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Y-39983 dihydrochloride, Y-33075 dihydrochloride supplier, ROCK, inhibitors

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