| Cat.No. | Name | Information |
|---|---|---|
| M1817 | Y-27632 dihydrochloride | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| M5168 | GSK269962A | GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively. |
| M7388 | TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active. |
| M4938 | H-1152 | H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| M1856 | Thiazovivin | Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. |
| M5123 | Y-39983 dihydrochloride | Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632. |
| M20278 | WAY-657460 | WAY-657460 is a ROCK inhibitor |
| M20277 | WAY-656935 | WAY-656935 is a ROCK Inhibitor |
| M20275 | WAY-655978 | WAY-655978 is a inhibitor of ROCK, ERK, GSK, and AGC protein kinases. |
| M20150 | WAY-346940 | WAY-346940 is a Rho-kinase inhibitor. |
| M20099 | WAY-322940 | WAY-322940 is a inhibitor of Rho kinase. |
| M13732 | SAR407899 hydrochloride | SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. |
| M13731 | ROCK inhibitor-2 | ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. |
| M13730 | RKI-1447 dihydrochloride | RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis. |
| M13729 | LX7101 | LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM. |
| M13728 | Hydroxyfasudil | Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. |
| M11034 | Netarsudil (AR-13324) 2HCl | Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. |
| M11024 | ROCK2-IN-2 | Rock2-in-2 is a selective ROCK2 inhibitor with IC50 <1 μM. |
| M6467 | AS 1892802 | AS 1892802 is a potent ROCK inhibitor; orally bioavailable. |
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