Free shipping on all orders over $ 500

ROCK inhibitor-2

Cat. No. M13731
ROCK inhibitor-2 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively.

Chemical Information
Molecular Weight 332.4
CAS Number 1127308-52-4
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Meenakshisundaram Balasubramaniam, et al. Biotechnol Appl Biochem. FCX-146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second-generation arylidene indanone scaffold

[2] Wei Du, et al. Stem Cells. SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells

[3] Ariane Roseblade, et al. Curr Cancer Drug Targets. Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance

[4] Asad Zeidan, et al. J Pharmacol Exp Ther. Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways

[5] Jin-Ran Chen, et al. J Pharmacol Exp Ther. Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts

Related ROCK Products
Akt/ROCK-IN-1

Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively.

Scaff10-8

Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation.

ROCK-IN-6

ROCK-IN-6 is a potent and selectiveROCK2 inhibitor with an IC50 of 2.19 nM.

ROCK-IN-4

ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability.

ROCK-IN-32

ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2.

  Catalog
Abmole Inhibitor Catalog




Keywords: ROCK inhibitor-2 supplier, ROCK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.