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BDP5290

Cat. No. M9211
BDP5290 Structure
Size Price Availability Quantity
2mg USD 121.5  USD135 In stock
5mg USD 202.5  USD225 In stock
10mg USD 333  USD370 In stock
25mg USD 702  USD780 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels at higher concentrations.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 371.82
Formula C17H18ClN7O
CAS Number 1817698-21-7
Purity >98%
Solubility DMSO: ≥ 10 mg/mL (Need ultrasonic)
Storage at -20°C
References

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges.
Gandalovicova A, et al. Trends Cancer. 2017 Jun;3(6):391-406. PMID: 28670628.

A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Unbekandt M, et al. Cell Commun Signal. 2014 Oct 5;12:54. PMID: 25288205.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BDP5290 supplier, ROCK, inhibitors

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