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3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels at higher concentrations.
| Molecular Weight | 371.82 |
| Formula | C17H18ClN7O |
| CAS Number | 1817698-21-7 |
| Solubility (25°C) | DMSO: ≥ 10 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ROCK Products |
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Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. |
| SR-3677 dihydrochloride
SR-3677 dihydrochloride is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM. |
| Akt/ROCK-IN-1
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| Scaff10-8
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