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Fasudil is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ antagonist and vasodilator. It also inhibits proliferation of vascular smooth muscle cells.
| Molecular Weight | 291.37 |
| Formula | C14H17N3O2S |
| CAS Number | 103745-39-7 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Yue Xi, et al. Therapeutic potentials of fasudil in liver fibrosis
[4] Kim Ann Saal, et al. Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics
[5] Yiqing Zhang, et al. Effects of fasudil on pulmonary hypertension in clinical practice
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