Free shipping on all orders over $ 500

ZCL278

Cat. No. M2562
ZCL278 Structure
Size Price Availability Quantity
10mg USD 73.8  USD82 In stock
50mg USD 234  USD260 In stock
100mg USD 351  USD390 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

Product Citations
Customer Product Validations & Biological Datas
Source International Journal of Nanomedicine (2018). Figure 5. ZCL278 (Abmole Bioscience, Houston, TX, USA)
Method RNA interference
Cell Lines A549 cells
Concentrations
Incubation Time 24 h
Results These findings indicated that Cdc42 played a vital role in the uptake of oxMWCNTs in A549 cells, while Rac1 and RhoA might not be involved in this process.
Source ACS Appl Mater Interfaces (2017). Figure 9. ZCL 278 (Abmole BioScience. Houston, TX, USA)
Method Transwells
Cell Lines MDCK cells
Concentrations
Incubation Time
Results As shown in Figure 9, in the presence of ZCL 278, the transmembrane amount of PTX-NCs was reduced significantly, indicating that Cdc 42 participated in the regulation of the transport of PTX-NCs.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 584.89
Formula C21H19BrClN5O4S2
CAS Number 587841-73-4
Purity >98%
Solubility DMSO 70 mg/mL
Storage at -20°C
Related Ras Products
CID-1067700 (ML282)

CID-1067700 (ML282) is a competitive inhibitors of nucleotide binding by Ras-related GTPases with a Ki of 13 nM for Rab7.

MLS000532223

MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM.

BI-3406

BI-3406 is a highly potent and selective SOS1::KRAS inhibitor (IC50=6 nM), which selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation.

ZT-12-037-01

ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively.

BI-2852

BI-2852 is a potent KRAS inhibitor that binds with nanomolar affinity to a pocket.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ZCL278 supplier, Ras, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.