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Ras Ras

Cat.No.  Name Information
M9428 MRTX849 (Adagrasib) MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor.
M9356 AMG-510 (Sotorasib) AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor.
M6282 NSC 23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
M2562 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
M40832 RAS-IN-2 RAS-IN-2 (RMC-6236) is a potent pan-KRAS inhibitor targeting activation-state KRAS for cancer-related studies.
M40499 BI-2865 BI-2865 is a non-covalent pan-KRAS inhibitor that binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with Kd values of 6.9 nM, 4.5 nM, 32 nM, 26 nM, and 4.3 nM, respectively.It can be used in studies related to KRAS mutant tumors.
M29707 Garsorasib Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM. Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer).
M27747 AZA1 AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.
M25612 RMC-6291
M21533 BI-0474 BI-0474 is a covalent KRASG12C inhibitor. The IC50 value for GDP-KRAS::SOS1 protein-protein interaction was 7.0 nM. BI-0474 also showed better antitumor activity in non-small cell lung cancer xenograft models.
M20013 MRTX0902 MRTX0902 is an oral brain penetrating SOS1:KRAS protein-protein interaction inhibitor.
M14058 Y16 Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM.
M14055 Pan-RAS-IN-1 Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
M14053 Deltarasin hydrochloride Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.
M11442 GDC-6036 GDC-6036 (compound 17a) An orally active, selective, covalently mutated KRAS G12C inhibitor with an IC50<0.01 μM for K-Ras G12C. GDC-6036 has an EC50 of 2 nM in K-Ras G12C-alkylated HCC1171 cells. can be used in studies related to non-small cell lung cancer ( NSCLC) related studies.
M11263 HJC0197 HJC0197 is a potent antagonist of Epac1 (the exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2). HJC0197 selectively blocked camp-induced Epac activation. HJC0197 inhibited epAC1-mediated RAP1-GDP exchange activity in the presence of isoconcentration of cAMP.
M11016 JDQ443 JDQ-443 (example 1a) is a covalent inhibitor of KRAS G12C.
M10978 Methylophiopogonanone B Methylophiopogonanone B, high isotinodihydroflavones, extracted from the roots of Wheat Dong, has a high antioxidant capacity. Methylophiopogonanone B increases GTP-Rho and works through the Rho signaling pathway, and Methylophiopogonanone B induces changes in cell morphology, including dendritic contraction and stress fiber formation, through actin cytoskeletal recombination.
M10600 SAH-SOS1A TFA SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM) and directly and independently blocks nucleotide association.
M10593 MRTX1133 MRTX1133 is a first-in-class, potent and highly selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells.




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