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AMG-510 (Sotorasib) selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant.
In preclinical tumor models, AMG 510 rapidly and irreversibly binds to KRAS G12C, providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. AMG 510 (orally, once daily) is capable of inducing tumor regression in mouse models of KRAS G12C cancer.
iScience. 2023 Jan 28;26(2):106080..
Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
AMG-510 (Sotorasib) purchased from AbMole
| Molecular Weight | 560.59 |
| Formula | C30H30F2N6O3 |
| CAS Number | 2296729-00-3 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] David S Hong, et al. KRAS G12C Inhibition with Sotorasib in Advanced Solid Tumors
[3] No authors listed. Cancer Discov. AMG 510 Shows Activity beyond NSCLC
[5] Jude Canon, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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