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 About 30 results found for searched term "Ras" (0.002 seconds)

Cat.No.  Name Information
M1645 AG14361 AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM.
M1663 AZD1152-HQPA AZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively.
M1664 AZD2281 (Olaparib) AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1676 BIBR1532 BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 93 nM.
M1681 BMS-707035 BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.
M1689 BTZ043 BTZ043 (BTZ038, BTZ044) is a decaprenylphosphoryl-b-D-ribose 2-epimerase inhibitor.
M1698 Clofarabine Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
M1728 GSK256066 GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM. *The compound is unstable in solutions, freshly prepared is recommended
M1754 WP1130 Degrasyn (WP1130) is a small molecular deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.
M11352 Coniferyl ferulate Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM.
M1785 INO-1001 INO-1001 is a novel poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 3 nM.
M1871 Roflumilast Roflumilast (trade names Daxas, Daliresp) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4).
M1885 Tipifarnib Tipifarnib (IND 58359) inhibited Farnesitransferase (FTase) with an IC50 of 0.86 nM. Tipifarnib has potential antitumor activity. Tipifarnib can inhibit exosome release of tumor cells.
M1895 Prasugrel hydrochloride Prasugrel hydrochloride is a novel inhibitor of platelet activation and aggregation.
M1906 Piclamilast Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4.
M1969 Doxorubicin HCL Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
M1979 Elvitegravir Elvitegravir (EVG) is a HIV integrase inhibitor with IC50 of 0.7 nM, 2.8 nM and 1.4 nM for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD, respectively.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M2010 BSI-401 BSI-401 is a novel poly (ADP ribose) polymerase-1 inhibitor.
M2024 BIX 01294 Trihydrochloride BIX 01294 Trihydrochloride is a potent inhitor of G9a histone methyltransferase with IC50 of 2.7 μM.
M2056 PJ34 hydrochloride PJ34 is a novel potent inhibitor of poly(ADP-ribose) polymerase (PARP) with EC50 of 20 nM.
M2089 Irinotecan Hydrochloride Trihydrate Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2114 GSK126 GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity.
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2145 Loperamide hydrochloride Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity with Ki values of 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively. Loperamide hydrochloride is also a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor.
M2179 EPZ-5676 EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase.
M2182 RG108 RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM.
M2198 Curcumin Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification.
M2199 Camptothecin Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.
M2217 Mitoxantrone dihydrochloride Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.

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