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Salirasib

Cat. No. M5946
Salirasib Structure
Synonym:

S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS

Size Price Availability Quantity
25mg USD 99  USD110 In stock
50mg USD 159.3  USD177 In stock
100mg USD 211.5  USD235 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 358.54
Formula C22H30O2S
CAS Number 162520-00-5
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.
Charette N, et al. Cell Death Dis. 2013 Jan 24;4:e471. PMID: 23348585.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Salirasib, S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS supplier, Ras, inhibitors

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