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6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.
| Molecular Weight | 590.14 |
| Formula | C22H31ClF3N3O4S3 |
| CAS Number | 1469338-01-9 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lu S, et al. Med Res Rev. Harnessing allostery: a novel approach to drug discovery.
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