Dryocrassin ABBA (Dryocrassin) is a natural product of flavonoids extracted from Sophora flavescens, with antiviral and antibacterial activities. Dryocrassin ABBA has antiviral activity against H5N1 avian influenza virus. Dryocrassin ABBA could inhibit coagulase activity of STaphylococcus aureus vWbp. Dryocrassin ABBA can inhibit the immune stimulation of dendritic cells and prolong the survival rate of allografts.
| Molecular Weight | 820.83 |
| Formula | C43H48O16 |
| CAS Number | 12777-70-7 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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