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Tirasemtiv (CK-2017357) slows the rate of calcium release from troponin C and sensitizes muscle to calcium. Tirasemtiv (CK-2017357) increases the production of muscle strength in situ at sub-maximal nerve stimulation rates. Single doses of 250 mg and 500 mg of Tirasemtiv were safe and well tolerated by patients with ALS. sensitization of the fast-skeletal-troponin complex to calcium improves muscle force and grip strength immediately after administration of single doses of Tirasemtiv in a model of the neuromuscular disease myasthenia gravis.
| Molecular Weight | 230.27 |
| Formula | C12H14N4O |
| CAS Number | 1005491-05-3 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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