| Cat.No. | Name | Information |
|---|---|---|
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M9356 | AMG-510 (Sotorasib) | AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. |
| M9428 | MRTX849 (Adagrasib) | MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M9047 | ARS-1630 | ARS-1630 is a novel mutant K-ras G12C inhibitor. |
| M9046 | ARS-1323 | ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
| M9045 | ARS-1620 | ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics. |
| M9000 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM. |
| M8954 | Kobe2602 | Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM. |
| M8533 | CCG-203971 | CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. |
| M7194 | Rhosin hydrochloride | Rhosin hydrochloride is a rho GTPase inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability. |
| M6968 | ML141 (CID-2950007) | ML141 (CID-2950007) is a selective inhibitor of Cdc42 Rho family GTPase. |
| M6748 | GGTI 298 Trifluoroacetate | GGTI 298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM. |
| M6704 | EHT 1864 2HCl | EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. |
| M5946 | Salirasib | Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. |
| M5481 | CASIN | CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. |
| M3885 | 6H05 trifluoroacetate | 6H05 is a selective and allosteric inhibitor of oncogenic K-Ras(G12C). |
| M3663 | K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
| M2608 | Kobe0065 | Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. |
| M58664 | AMG410 | AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. |
| M58646 | HRS-4642 | HRS-4642 is a selective KRAS(G12D) inhibitor, with Kd value of 0.083 nM. HRS-4642 has anti-cancer activity. HRS-4642 exhibits significant in vivo potency. |
| M58645 | AZD0022 | AZD0022 is a selective and orally active KRASG12D inhibitor. |
| M56329 | HH0043 | HH0043 is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. |
| M56328 | BI-2493 | BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. |
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