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BI-2852 is a KRAS inhibitor for the switch I/II pocket. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitors because it binds to a different pocket present in both the active and inactive forms of KRAS. BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. BI-2852 (10 nM-10 µM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 5.8 µM and 6.7 µM in soft agar and low serum conditions in NCI-H358 cells.
| Molecular Weight | 516.59 |
| Formula | C31H28N6O2 |
| CAS Number | 2375482-51-0 |
| Solubility (25°C) | DMSO ≥ 37 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related Ras Products |
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| HH0043
HH0043 is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. |
| BI-2493
BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. |
| D3S-001
D3S-001 is an orally active inhibitor for KRAS. |
| MK-1084
MK-1084 is a selective KRAS G12C inhibitor. |
| ADT-007
ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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