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ML-098

Cat. No. M9000
ML-098 Structure
Synonym:

CID-7345532

Size Price Availability Quantity
10mg USD 135  USD150 In stock
50mg USD 495  USD550 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM. ML098 (CID-7345532) increased the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 309.36
Formula C19H19NO3
CAS Number 878978-76-8
Purity >98%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Three small molecule pan activator families of Ras-related GTPases.
Surviladze Z, et al. Probe Reports from the NIH Molecular Libraries Program. 2009 May 18. PMID: 21433375.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ML-098, CID-7345532 supplier, Ras, inhibitors

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