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ML-098

Cat. No. M9000
ML-098 Structure
Synonym:

CID-7345532

Size Price Availability Quantity
10mg USD 150  USD150 In stock
50mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM. ML098 (CID-7345532) increased the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II.

Chemical Information
Molecular Weight 309.36
Formula C19H19NO3
CAS Number 878978-76-8
Solubility (25°C) DMSO: ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Surviladze Z, et al. Probe Reports from the NIH Molecular Libraries Program. Three small molecule pan activator families of Ras-related GTPases.

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Keywords: ML-098, CID-7345532 supplier, Ras, inhibitors, activators


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