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MLS000532223

Cat. No. M9817
MLS000532223 Structure
Size Price Availability Quantity
5mg USD 342  USD380 In stock
10mg USD 522  USD580 In stock
50mg USD 1566  USD1740 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 251.24
Formula C15H9NO3
CAS Number 16616-39-0
Purity >99%
Solubility DMSO ≥ 45 mg/mL
Storage at -20°C
References

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay
Zurab Surviladze, et al. J Biomol Screen. 2010 Jan;15(1):10-20. PMID: 20008126.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MLS000532223 supplier, Ras, inhibitors

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