| Cat.No. | Name | Information |
|---|---|---|
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M9356 | AMG-510 | AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. |
| M9428 | MRTX849 (Adagrasib) | MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M7194 | Rhosin hydrochloride | Rhosin hydrochloride is a rho GTPase inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability. |
| M6968 | ML141 (CID-2950007) | ML141 (CID-2950007) is a selective inhibitor of Cdc42 Rho family GTPase. |
| M6748 | GGTI 298 Trifluoroacetate | GGTI 298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM. |
| M6704 | EHT 1864 2HCl | EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. |
| M5946 | Salirasib | Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. |
| M5481 | CASIN | CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. |
| M3885 | 6H05 trifluoroacetate | 6H05 is a selective and allosteric inhibitor of oncogenic K-Ras(G12C). |
| M3663 | K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
| M2608 | Kobe0065 | Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. |
| M58645 | AZD0022 | AZD0022 is a selective and orally active KRASG12D inhibitor. |
| M56329 | HH0043 | HH0043 is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. |
| M56327 | D3S-001 | D3S-001 is an orally active inhibitor for KRAS. |
| M56325 | ADT-007 | ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects. |
| M56324 | (R)-CE3F4 | (R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). |
| M56322 | GGTI-297 | GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. |
| M56320 | MLS-573151 | MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. |
| M56319 | K-Ras G12C-IN-3 | K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| M52906 | KRpep-2d | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. |
| M52905 | Rac1 Inhibitor W56 | Rac1 Inhibitor W56 is a peptide containing residues 45-60 of Rac1. |
| M52904 | SAH-SOS1A | SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. |
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