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Ras Ras

Cat.No.  Name Information
M2562 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
M6282 NSC 23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
M9356 AMG-510 (Sotorasib) AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor.
M9428 MRTX849 (Adagrasib) MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor.
M8999 CCG-1423 CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling.
M56327 D3S-001  D3S-001 is an orally active inhibitor for KRAS.
M56326 MK-1084  MK-1084 is a selective KRAS G12C inhibitor.
M56325 ADT-007  ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects.
M56324 (R)-CE3F4  (R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM).
M56322 GGTI-297  GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively.
M56320 MLS-573151 MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM.
M56319 K-Ras G12C-IN-3  K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
M55031 BBO-8520 BBO-8520 is a first-in-class orally active covalent KRAS G12C inhibitor. BBO-8520 inhibits KRASG12C (ON) by locking the GTP-binding protein in state 1, a conformation incapable of binding effectors, thereby inhibiting the downstream signaling of KRASG12C (ON) that promotes cell proliferation. BBO-8520 also rapidly and completely blocks the RAS-RAF1 interaction, returning KRASG12C to its inactive (OFF) state.
M52906 KRpep-2d KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells.
M52905 Rac1 Inhibitor W56 Rac1 Inhibitor W56 is a peptide containing residues 45-60 of Rac1.
M52904 SAH-SOS1A SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor.
M49728 K20 K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 µM.
M49478 RMC-8839 RMC-8839 is an orally available, mutant-selective, direct inhibitor of KRAS G13C.
M49477 YL-17231 YL-17231 is a pan-KRAS mutant oral small molecule inhibitor in combination with the KRAS switch II pocket for studies related to KRAS mutant solid tumors.
M49368 RM-032 RM-032 is an orally active KRAS inhibitor that covalently binds to KRAS G12C and procyclin A to inhibit RAS pathway signaling and cell proliferation in KRAS G12C tumor cells.
M49367 SML-8-73-1 SML-8-73-1 is a GDP analog and also a KRAS inhibitor that irreversibly covalently binds to the GTPase active site of KRAS, and its binding rate to KRAS G12C was more than 95% in a 1 mmol/L GDP/GTP environment, and the IC 50 value for the inhibition of the proliferation of lung cancer cells H358 was 26.6 μmol/L .
M45215 ABSK071 ABSK071 is a novel KRAS G12C inhibitor with antitumor activity.
M45162 BI 1823911 BI 1823911 is a novel, highly selective, covalently irreversible oral small molecule inhibitor of KRASG12C.
M45161 ARS-3248 ARS-3248 is a novel KRAS G12C inhibitor.
M45160 LY3499446 LY3499446 is a KRAS G12C covalent inhibitor for studies related to non-small cell lung cancer (NSCLC).




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