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GGTI 298 Trifluoroacetate is a cAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. GGTI 298 Trifluoroacetate strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). GGTI 298 Trifluoroacetate causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.
| Molecular Weight | 593.66 |
| Formula | C27H33N3O3S.CF3CO2H |
| CAS Number | 1217457-86-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ras Products |
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AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. |
| HRS-4642
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| HH0043
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| BI-2493
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