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CASIN

Cat. No. M5481
CASIN  Structure
Size Price Availability Quantity
10mg USD 144  USD144 In stock
50mg USD 536  USD536 In stock
100mg USD 868  USD868 In stock
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Quality Control
Biological Activity

CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 306.4
Formula C20H22N2O
CAS Number 425399-05-9
Purity 99.91%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

[1] Gál ZA, et al. Inorg Chem. Synthesis and structure of alkaline earth silicon nitrides: BaSiN(2), SrSiN(2), and CaSiN(2).

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CASIN supplier, Ras, inhibitors

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