| Cat.No. | Name | Information |
|---|---|---|
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M9356 | AMG-510 (Sotorasib) | AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. |
| M9428 | MRTX849 (Adagrasib) | MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M41935 | KRAS inhibitor-22 | KRAS inhibitor-22 is a potent inhibitor of K-Ras. |
| M41934 | pan-KRAS-IN-3 | pan-KRAS-IN-3 is a pan-KRAS inhibitor. |
| M41933 | KRASG12C IN-2 | KRASG12C IN-2 is an orally active KRASG12C inhibitor. |
| M41932 | Rac1-IN-3 | Rac1-IN-3 is a Rac1 inhibitor with an IC50 of 46.1 μM. |
| M41931 | PAT-IN-2 | PAT-IN-2 is a protein acyl transferases (PAT) inhibitor. |
| M41930 | PAT-IN-1 | PAT-IN-1 is a protein acyl transferases (PAT) inhibitor. |
| M41929 | RMC-4998 | RMC-4998 is a molecular glue compound with good antitumor activity. |
| M41928 | SCH54292 | SCH54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 μM. |
| M41927 | KRAS G12C inhibitor 58 | KRAS G12C inhibitor 58 is a KRAS G12C inhibitor, used in cancer research. |
| M41926 | SOS1-IN-16 | SOS1-IN-16 is a selective inhibitor of SOS1 with an IC50 of 7.2 nM. |
| M41925 | PROTAC KRAS G12C degrader-3 | PROTAC KRAS G12C degrader-3 is a potent KRAS G12C degrader for cancer research. |
| M41924 | pan-KRAS-IN-4 | pan-KRAS-IN-4 is a potent inhibitor of KRAS with IC50s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively. |
| M41923 | TH-Z816 | TH-Z816 is a reversible inhibitor againstKRAS(G12D)mutation with an IC50 value of 14 μM, which can be used in cancer research. |
| M41922 | MRTF/SRF-IN-1 | MRTF/SRF-IN-1 is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). |
| M41921 | Spiclomazine | Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. |
| M41920 | KRAS G12D modulator-1 | KRAS G12D modulator-1 is a potent KRAS G12D modulator with IC50 values of 1-10 μM for NEA-G12D, PPI-G12D, and p ERK-AGS, respectively. |
| M41919 | pan-KRAS-IN-2 | pan-KRAS-IN-2 is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively. |
| M38969 | (-)-Rasfonin | (-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line). |
| M31040 | GGTI-286 TFA | GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276. GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM. |
| M30865 | NSC-658497 | NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation. |
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