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Spiclomazine

Cat. No. M41921

All AbMole products are for research use only, cannot be used for human consumption.

Spiclomazine Structure

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Quality Control & Documentation
Biological Activity

Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer.

Chemical Information
Molecular Weight 446.03
Formula C22H24ClN3OS2
CAS Number 24527-27-3
Form Solid
Solubility (25°C) DMSO 110 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiaoyu Guo et al. Oncotarget. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer

[2] Wenjing Zhao et al. PLoS One. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells

[3] H Kuribara et al. Pharmacol Biochem Behav. Correlation between antiavoidance activities of antipsychotic drugs in rats and daily clinical doses

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Keywords: Spiclomazine supplier, Ras, inhibitors, activators

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