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NAV-2729 is a selective ARF6 inhibitor with IC50 value of 1.0 μM. NAV-2729 reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model, confirming the functional relevance of this pathway and suggesting a therapeutic strategy for Gα-mediated diseases.
| Molecular Weight | 456.88 |
| Formula | C25H17ClN4O3 |
| CAS Number | 419547-11-8 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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