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ARS-1630

Cat. No. M9047
ARS-1630 Structure
Size Price Availability Quantity
5mg USD 380  USD380 In stock
10mg USD 610  USD610 In stock
25mg USD 1100  USD1100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ARS-1630 is a novel mutant K-ras G12C inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 430.84
Formula C21H17ClF2N4O2
CAS Number 1698055-86-5
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
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RM-018

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HJC0197

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ARS-1630 supplier, Ras, inhibitors

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