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ARS-1323

Cat. No. M9046
ARS-1323 Structure
Size Price Availability Quantity
5mg USD 650  USD650 In stock
10mg USD 1200  USD1200 In stock
25mg USD 2600  USD2600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ARS-1323 is a novel inhibitor of mutant K-ras G12C.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 430.84
Formula C21H17ClF2N4O2
CAS Number 1698024-73-5
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

[1] Peter D Koch, et al. SMALL MOLECULE IMAGING AGENT FOR MUTANT KRAS G12C

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ARS-1323 supplier, Ras, inhibitors

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