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SAH-SOS1A TFA

Cat. No. M10600

All AbMole products are for research use only, cannot be used for human consumption.

SAH-SOS1A TFA Structure
Size Price Availability Quantity
5mg USD 420  USD420 In stock
10mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM) and directly and independently blocks nucleotide association. SAH-SOS1A TFA (0.625-40 μM; 24 hours) dose-responsively impairs the viability of cancer cells bearing G12D, G12C, G12V, G12S, G13D, and Q61H mutations with IC50 values in the 5- to 15-μM range. Cancer cells expressing wild-type KRAS, such as HeLa and Colo320-HSR cells, are similarly affected.

In vivo, SAH-SOS1A (0.2 μL of 10 mM solution; injection; 48 hours; abdomens of D. melanogaster Ras85DV12/ActinGS) treatment notably decreases the phosphorylation state of ERK1/2.

Sequence: Arg-Arg-Phe-Phe-Gly-Ile-Aaa-Leu-Thr-Asn-Aaa-Leu-Lys-Thr-Glu-Glu-Gly-Asn (Covalent bridge: Aaa7-Aaa11)

Chemical Information
Molecular Weight 2301.55
Formula C102H160N27F3O30
CAS Number 1652561-87-9 (free base)
Storage -20°C, protect from light, sealed
References

[1] Elizaveta S Leshchiner, et al. Proc Natl Acad Sci U S A. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

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  Catalog
Abmole Inhibitor Catalog




Keywords: SAH-SOS1A TFA supplier, Ras, inhibitors, activators

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