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AMG-510 racemate

Cat. No. M9357
AMG-510 racemate Structure
Size Price Availability
10mg USD 350  USD350 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor. AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 560.59
Formula C30H30F2N6O3
CAS Number 2252403-56-6
Purity >98%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
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RM-018

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HJC0197

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SAH-SOS1A TFA

SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM) and directly and independently blocks nucleotide association.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AMG-510 racemate supplier, Ras, inhibitors

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