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8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.
| Molecular Weight | 507.82 |
| Formula | C17H16ClN5NaO6PS |
| CAS Number | 634207-53-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, dry, sealed |
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