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ZINC69391 

Cat. No. M29868

All AbMole products are for research use only, cannot be used for human consumption.

ZINC69391  Structure

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Quality Control & Documentation
Biological Activity

ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects.

Chemical Information
Molecular Weight 309.29
Formula C14H14F3N5
CAS Number 303094-67-9
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anette Lodvir Hemsing, et al. Biomedicines. NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition

[2] Maia Cabrera, et al. Oncotarget. Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

[3] Georgina A Cardama, et al. Onco Targets Ther. Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

[4] Georgina A Cardama, et al. Anticancer Agents Med Chem. Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines

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Keywords: ZINC69391  supplier, Ras, inhibitors, activators

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